Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma
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چکیده
منابع مشابه
Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma.
This study was aimed at evaluating the potential application of benzophenanthridine alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer. In vitro antiproliferative activity of sanguinarine was higher than that of cheleritrine against the B16 melanoma 4A5 cells. Both agents were able to produce DNA breaks, and the DNA unwinding assay showed that they act as DNA intercalat...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2009
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2009.07.011